RNA Details
Disease Name
lens fibrosis
Tissue
eye
RNA Symbol
mir-26a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
JAGGED-1
Pathway
JAG1; NOTCH SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway
Year
2017
Function
"We revealed that the mechanisms of anti-emt effects of mir-26a and -26b are via directly targeting jagged-1 and suppressing jagged-1;Notch signaling. Furthermore, we provided in vitro and in vivo evidence that jagged-1;Notch signaling is activated in tgfbeta2-stimulated emt, and blockade of notch signaling can reverse lens epithelial cells (lecs) emt and lens fibrosis.?"